Synthesis and Characterization of Substituted Starch Grafted Methyl Nadic Anhydride and Substituted with 4-Aminoantipyrine

  • Firyal M. Ali Department of Chemistry, College of Science, Al-Mustansiriya University, Baghdad, Iraq
  • Mohammed A. Farhan Department of Chemistry, College of Science, Diyala University, Diyala, Iraq
DOI: https://doi.org/10.34198/ejcs.1219.103113
Keywords: starch, methyl nadic anhydride, 4-aminoantipyrine, copolymer, drug copolymer

Abstract

In this research the structural modification of starch was carried out with methyl nadic anhydride (M1) as a spacer by using ceric ammonium nitrate (CAN) as an initiator, and grafted copolymer was substituted with amino drug such as 4-aminoantipyrine (M1B), this design of carries for controlled delivery of therapeutic agent which could release the entrapped drug over an extended period of time, due to its nontoxic, biodegradable and slow digesting nature, the new drug copolymer was characterized by FTIR, 1H-NMR and UV Spectroscopes. The prepared drug copolymer was analyzed in different pH values at (37°C) as in vitro study and controlled drug release was compared at zero time and after four days.

Published
2019-03-15
How to Cite
Ali , F. M., & Farhan , M. A. (2019). Synthesis and Characterization of Substituted Starch Grafted Methyl Nadic Anhydride and Substituted with 4-Aminoantipyrine. Earthline Journal of Chemical Sciences, 1(2), 103-113. https://doi.org/10.34198/ejcs.1219.103113
Issue
Vol 1 No 2 (2019)
Section
Articles


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