Cystodytin L, a Pyridoacridine Alkaloid from the Senegalese Tunicate Cystodytes sp.

  • Mohamet Diop Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP: 5005, Dakar Fann, Sénégal
  • Abou Moussa Sow Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP: 5005, Dakar Fann, Sénégal
  • Mouhamadou Fofana Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP: 5005, Dakar Fann, Sénégal
  • Bédié Mbow Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP: 5005, Dakar Fann, Sénégal
  • Dior Samb Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop, BP: 5005, Dakar Fann, Sénégal
Keywords: tunicate, Cystodytes sp., cystodytin, pyridoacridine alkaloids, marine metabolites

Abstract

Chemical investigation of the brown-colored tunicate Cystodytes sp. yielded six pyridoacridine alkaloids, including the known metabolites arnoamine C (1), styelsamine C (2), cystodytin B (3), E (4) and G (5) and the new compound, cystodytin L (6).

Their chemical structures were established on the basis of combination of [α]D, physical and spectroscopic methods 1D and 2D NMR, in addition to mass spectrometry and comparison with literature data. The absolute configuration of C-12 in compounds 4-6 was identified as R by electronic circular dichroism (ECD) spectroscopy coupled with time-dependent density functional theory calculations.

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Published
2022-11-27
How to Cite
Diop, M., Sow, A. M., Fofana, M., Mbow, B., & Samb, D. (2022). Cystodytin L, a Pyridoacridine Alkaloid from the Senegalese Tunicate Cystodytes sp. Earthline Journal of Chemical Sciences, 9(2), 177-188. https://doi.org/10.34198/ejcs.9223.177188
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Articles