Nаtural Antioxidants and their Effect on Human Health
Abstract
Fruit, vegetables and spice antioxidants are recognized for their important role in human health against some diseases for instance cancer and cardiovascular diseases. Phenolic antioxidants, vitamins (C and E), flavonoids, and cаtеchins are among the major nаturally bioavailable antioxidants. Nаtural antioxidants positive impact on human health can be summarized on their potential to act against inflammation, bacteria, aging, oxidаtive stress and cаncer. The evaluation of antioxidants bioavailability in food and medicinal plants are essential to understand the best antioxidant sources and to elevate their use in food, pharmaceuticals and food additives.
References
Halliwell, B. (1990). How to characterize a biological antioxidant. Free Radical Research Communications, 9(1), 1-32. https://doi.org/10.3109/10715769009148569
Akram, S., Amir, R.M., Nadeem, M., Sattar, M.U., & Faiz, F. (2012). Antioxidant potential of black tea (Camellia sinensis L.)-A review. Pak. J. Food Sci., 22(3), 128-132.
Maestri, D.M., Nepote, V., Lamarque, A.L., & Zygadlo, J.A. (2006). Natural products as antioxidants. Phytochemistry: Advances in Research, 37(661), 105-135.
Mandal, S., Yadav, S., Yadav, S., & Nema, R.K. (2009). Antioxidants: a review. Journal of Chemical and Pharmaceutical Research, 1(1), 102-104.
Ou Huang, D., Hampsch-Woodil, M., Judith, A., Flanagan, K.D., & Elizabeth, K.D. (2002). Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: A comparative study. Journal of Agricultural Food Chemistry, 50(11), 3122-3128. https://doi.org/10.1021/jf0116606
Ahmed, S., & Beigh, S.H. (2009). Ascorbic acid, carotenoids, total phenolic content and antioxidant activity of various genotypes of Brassica Oleracea encephala. Journal of Medical and Biological Sciences, 3(1), 1-8.
Nimse, S.B., & Pal, D. (2015). Free radicals, natural antioxidants, and their reaction mechanisms. RSC Advances, 5(35), 27986-28006. https://doi.org/10.1039/C4RA13315C
Gupta, V.K., & Sharma, S.K. (2006). Plants as natural antioxidants. Nat. Product. Radiance, 5, 326-334.
Sen, S., & Chakraborty, R. (2011). The role of antioxidants in human health. In Oxidative stress: diagnostics, prevention, and therapy (pp. 1-37). American Chemical Society. https://doi.org/10.1021/bk-2011-1083.ch001
Li, Y. (2011). Antioxidants in biology and medicine: essentials, advances, and clinical applications. Nova Science Publishers.
Pokorný, J. (1991). Natural antioxidants for food use. Trends in Food Science & Technology, 2, 223-227. https://doi.org/10.1016/0924-2244(91)90695-F
Suh, H.J., Chung, M.S., Cho, Y.H., Kim, J.W., Kim, D.H., Han, K.W., & Kim, C.J. (2005). Estimated daily intakes of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert-butyl hydroquinone (TBHQ) antioxidants in Korea. Food Additives and Contaminants, 22(12), 1176-1188. https://doi.org/10.1080/02652030500195288
Pratt, D.E., & Hudson, B.J. (1990). Natural antioxidants not exploited commercially. In Food antioxidants (pp. 171-191). Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0753-9_5
Mathew, S., & Abraham, T.E. (2006). Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chemistry, 94(4), 520-528. https://doi.org/10.1016/j.foodchem.2004.11.043
Akbarirad, H., Ardabili, A.G., Kazemeini, S.M., & Khaneghah, A.M. (2016). An overview on some of important sources of natural antioxidants. International Food Research Journal, 23(3), 928-933.
Arshiya, S. (2013). The antioxidant effect of certain fruits: - A review. Journal of Pharmaceutical Sciences and Research, 5(12), 265-268.
Parashar, S., Sharma, H., & Garg, M. (2014). Antimicrobial and antioxidant activities of fruits and vegetable peels: A review. Journal of Pharmacognosy and Phytochemistry, 3(1), 160-164.
Karrar, E.A. (2014). A review on: Antioxidant and its impact during the bread making process. Int. J. Nutr. Food Sci. 3, 592-596. https://doi.org/10.11648/j.ijnfs.20140306.26
Thasleema, S.A. (2013). Green tea as an antioxidant-a short review. Journal of Pharmaceutical Sciences and Research, 5(9), 171.
Perron, N.R., & Brumaghim, J.L. (2009). A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochemistry and Biophysics, 53(2), 75-100. https://doi.org/10.1007/s12013-009-9043-x
Nardini, M., Cirillo, E., Natella, F., & Scaccini, C. (2002). Absorption of phenolic acids in humans after coffee consumption. Journal of Agricultural and Food Chemistry, 50(20), 5735-5741. https://doi.org/10.1021/jf0257547
Ghatak, A.A., Chaturvedi, P.A., & Desai, N.S. (2014). Indian grape wines: a potential source of phenols, polyphenols, and antioxidants. International Journal of Food Properties, 17(4), 818-828. https://doi.org/10.1080/10942912.2012.675608
Sikora, E., Cieślik, E., & Topolska, K. (2008). The sources of natural antioxidants. Acta Scientiarum Polonorum Technologia Alimentaria, 7(1), 5-17.
Alok, S., Jain, S. K., Verma, A., Kumar, M., Mahor, A., & Sabharwal, M. (2014). Herbal antioxidant in clinical practice: A review. Asian Pacific Journal of Tropical Biomedicine, 4(1), 78-84. https://doi.org/10.1016/S2221-1691(14)60213-6
Charles, D.J. (2012). Rosemary. In Antioxidant properties of spices, herbs and other sources (pp. 495-507), New York: Springer. https://doi.org/10.1007/978-1-4614-4310-0_48
Hägg, M., Ylikoski, S., & Kumpulainen, J. (1995). Vitamin C content in fruits and berries consumed in Finland. Journal of Food Composition and Analysis, 8(1), 12-20. https://doi.org/10.1006/jfca.1995.1003
Benvenuti, S., Pellati, F., Melegari, M.A., & Bertelli, D. (2004). Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia. Journal of Food Science, 69(3), FCT164-FCT169. https://doi.org/10.1111/j.1365-2621.2004.tb13352.x
Olsson, M.E., Gustavsson, K.E., Andersson, S., Nilsson, Å., & Duan, R.D. (2004). Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. Journal of Agricultural and Food Chemistry, 52(24), 7264-7271. https://doi.org/10.1021/jf030479p
Kähkönen, M.P., Hopia, A.I., Vuorela, H.J., Rauha, J.P., Pihlaja, K., Kujala, T.S., & Heinonen, M. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agricultural and Food Chemistry, 47, 3954-3962. https://doi.org/10.1021/jf990146l
Klopotek, Y., Otto, K., & Böhm, V. (2005). Processing strawberries to different products alters contents of vitamin C, total phenolics, total anthocyanins, and antioxidant capacity. Journal of Agricultural and Food Chemistry, 53(14), 5640-5646. https://doi.org/10.1021/jf047947v
Gorinstein, S., Martı́n-Belloso, O., Park, Y.S., Haruenkit, R., Lojek, A., Ĉı́ž, M., Caspi, A., Libman, I., & Trakhtenberg, S. (2001). Comparison of some biochemical characteristics of different citrus fruits. Food Chemistry, 74(3), 309-315. https://doi.org/10.1016/S0308-8146(01)00157-1
Lugasi, A., Bíró, L., Hóvárie, J., Sági, K.V., Brandt, S., & Barna, É. (2003). Lycopene content of foods and lycopene intake in two groups of the Hungarian population. Nutrition Research, 23(8), 1035-1044. https://doi.org/10.1016/S0271-5317(03)00105-2
Saura-Calixto, F., Serrano, J., & Goñi, I. (2007). Intake and bioaccessibility of total polyphenols in a whole diet. Food Chemistry, 101(2), 492-501. https://doi.org/10.1016/j.foodchem.2006.02.006
Kähkönen, M.P., Hopia, A.I., & Heinonen, M. (2001). Berry phenolics and their antioxidant activity. Journal of Agricultural and Food Chemistry, 49(8), 4076-4082. https://doi.org/10.1021/jf010152t
Andrés-Lacueva, C., Medina-Remon, A., Llorach, R., Urpi-Sarda, M., Khan, N., Chiva-Blanch, G., Zamora‐Ros, R., Rotches‐Ribalta, M., & Lamuela-Raventos, R. M. (2009). Phenolic compounds: chemistry and occurrence in fruits and vegetables. In Fruit and vegetable phytochemicals: chemistry, nutritional value and stability. https://doi.org/10.1002/9780813809397.ch2
Lu, Y., & Foo, L.Y. (2000). Antioxidant and radical scavenging activities of polyphenols from apple pomace. Food Chemistry, 68(1), 81-85. https://doi.org/10.1016/S0308-8146(99)00167-3
Paganga, G., Miller, N., & Rice-Evans, C.A. (1999). The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute?. Free Radical Research, 30(2), 153-162. https://doi.org/10.1080/10715769900300161
Prior, R.L., & Cao, G. (2000). Antioxidant phytochemicals in fruits and vegetables: diet and health implications. HortScience, 35(4), 588-592. https://doi.org/10.21273/HORTSCI.35.4.588
Willcox, J.K., Catignani, G.L., & Lazarus, S. (2003). Tomatoes and cardiovascular health. Critical Reviews in Food Science and Nutrition, 43(1), 1-18. https://doi.org/10.1080/10408690390826437
Sahlin, E., Savage, G.P., & Lister, C.E. (2004). Investigation of the antioxidant properties of tomatoes after processing. Journal of Food Composition and Analysis, 17(5), 635-647. https://doi.org/10.1016/j.jfca.2003.10.003
Friedman, M. (2002). Tomato glycoalkaloids: role in the plant and in the diet. Journal of Agricultural and Food Chemistry, 50(21), 5751-5780. https://doi.org/10.1021/jf020560c
Arab, L., & Steck, S. (2000). Lycopene and cardiovascular disease. The American Journal of Clinical Nutrition, 71(6), 1691S-1695S. https://doi.org/10.1093/ajcn/71.6.1691S
Rissanen, T.H., Voutilainen, S., Nyyssönen, K., Lakka, T.A., Sivenius, J., Salonen, R., Kaplan, G.A., & Salonen, J.T. (2001). Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. British Journal of Nutrition, 85(6), 749-754. https://doi.org/10.1079/BJN2001357
Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. Journal of the National Cancer Institute, 91(4), 317-331. https://doi.org/10.1093/jnci/91.4.317
Krinsky, N.I. (1994). The biological properties of carotenoids. Pure and Applied Chemistry, 66(5), 1003-1010. https://doi.org/10.1351/pac199466051003
Howard, L.R., Talcott, S.T., Brenes, C.H., & Villalon, B. (2000). Changes in phytochemical and antioxidant activity of selected pepper cultivars (Capsicum species) as influenced by maturity. Journal of Agricultural and Food Chemistry, 48(5), 1713-1720. https://doi.org/10.1021/jf990916t
Al‐Saikhan, M.S., Howard, L.R., & Miller Jr., J.C. (1995). Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum, L.). Journal of Food Science, 60(2), 341-343. https://doi.org/10.1111/j.1365-2621.1995.tb05668.x
Tripathi, R.K., & Verma, M.N. (1975). Phenolic compounds and polyphenol oxidase activity in relation to resistance in potatoes against bacterial soft rot. Indian Journal of Experimental Biology, 13, 414-416.
Thomas, P., & Joshi, M.R. (1977). Prevention of after-cooking darkening of irradiated potatoes. Potato Research, 20(1), 77-84. https://doi.org/10.1007/BF02362302
Hamouz, K., Lachman, J., Dvorak, P., Duskova, O., Cizek, M., & Vyzkumny Ustav Bramborarsky, H. B. (2007). Effect of conditions of locality, variety and fertilization on the content of ascorbic acid in potato tubers. Plant Soil and Environment, 53(6), 252. https://doi.org/10.17221/2217-PSE
Jaiswal, A.K., Rajauria, G., Abu-Ghannam, N., & Gupta, S. (2011). Phenolic composition, antioxidant capacity and antibacterial activity of selected Irish Brassica vegetables. Natural Product Communications, 6(9), 1934578X1100600923. https://doi.org/10.1177/1934578X1100600923
Holasova, M., Fiedlerova, V., Smrcinova, H., Orsak, M., Lachman, J., & Vavreinova, S. (2002). Buckwheat—the source of antioxidant activity in functional foods. Food Research International, 35(2-3), 207-211. https://doi.org/10.1016/S0963-9969(01)00185-5
Peterson, D.M., Emmons, C.L., & Hibbs, A.H. (2001). Phenolic antioxidants and antioxidant activity in pearling fractions of oat groats. Journal of Cereal Science, 33(1), 97-103. https://doi.org/10.1006/jcrs.2000.0347
Drużyńska, B., & Klepacka, M. (2004). Właściwości przeciwutleniajace preparatów polifenoli otrzymanych z okrywy nasiennej fasoli czarnej, różowej i białej (Phaseolus)[The antioxidant properties of polyphenol preparations obtained from black, pink, and white bean seed coats (Phaseolus)]. Żywność, 4(41), 69-78.
Amarowicz, R., & Troszynska, A. (2005). Aktywnosc przeciwutleniajaca i zdolnosc redukcyjna ekstraktu z czerwonej fasoli i jego frakcji. Bromatologia i Chemia Toksykologiczna, 2(38), 119-124.
Khan, N., & Mukhtar, H. (2013). Tea and health: studies in humans. Current Pharmaceutical Design, 19(34), 6141-6147. https://doi.org/10.2174/1381612811319340008
Chu, C., Deng, J., Man, Y., & Qu, Y. (2017). Green tea extracts epigallocatechin-3-gallate for different treatments. BioMed Research International, 2017, Article ID 5615647. https://doi.org/10.1155/2017/5615647
Cieślik, E., Gręda, A., & Adamus, W. (2006). Contents of polyphenols in fruit and vegetables. Food Chemistry, 94(1), 135-142. https://doi.org/10.1016/j.foodchem.2004.11.015
Pohl, F., & Kong Thoo Lin, P. (2018). The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules, 23(12), 3283. https://doi.org/10.3390/molecules23123283
Ho, H.H., Chang, C.S., Ho, W.C., Liao, S.Y., Wu, C.H., & Wang, C.J. (2010). Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals. Food and Chemical Toxicology, 48(8-9), 2508-2516. https://doi.org/10.1016/j.fct.2010.06.024
Al-Rasheed, N.M., Fadda, L.M., Ali, H.M., Abdel Baky, N.A., El-Orabi, N.F., Al-Rasheed, N.M., & Yacoub, H.I. (2016). New mechanism in the modulation of carbon tetrachloride hepatotoxicity in rats using different natural antioxidants. Toxicology Mechanisms and Methods, 26(4), 243-250. https://doi.org/10.3109/15376516.2016.1159769
Del Bo, C., Martini, D., Bernardi, S., Gigliotti, L., Marino, M., Gargari, G., Meroño, T., Hidalgo-Liberona, N., Andres-Lacueva, C., Kroon, P.A., Cherubini, A., & Riso, P. (2021). Association between food intake, clinical and metabolic markers and DNA damage in older subjects. Antioxidants, 10(5), 730. https://doi.org/10.3390/antiox10050730
Angeloni, C., Malaguti, M., Barbalace, M.C., & Hrelia, S. (2017). Bioactivity of olive oil phenols in neuroprotection. International Journal of Molecular Sciences, 18(11), 2230. https://doi.org/10.3390/ijms18112230
Barbalace, M.C., Zallocco, L., Beghelli, D., Ronci, M., Scortichini, S., Digiacomo, M., Macchia, M., Mazzoni, M.R., Fiorini, D., Lucacchini, A. and Hrelia, S., (2021). Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy). Antioxidants, 10(3), p.421. https://doi.org/10.3390/antiox10030421
Pruccoli, L., Morroni, F., Sita, G., Hrelia, P., & Tarozzi, A. (2020). Esculetin as a bifunctional antioxidant prevents and counteracts the oxidative stress and neuronal death induced by amyloid protein in SH-SY5Y cells. Antioxidants, 9(6), 551. https://doi.org/10.3390/antiox9060551
Capatina, L., Boiangiu, R.S., Dumitru, G., Napoli, E.M., Ruberto, G., Hritcu, L., & Todirascu-Ciornea, E. (2020). Rosmarinus officinalis essential oil improves scopolamine-induced neurobehavioral changes via restoration of cholinergic function and brain antioxidant status in Zebrafish (Danio rerio). Antioxidants, 9(1), 62. https://doi.org/10.3390/antiox9010062
Garcia-Medina, J.J., Rubio-Velazquez, E., Lopez-Bernal, M.D., Cobo-Martinez, A., Zanon-Moreno, V., Pinazo-Duran, M.D., & del-Rio-Vellosillo, M. (2020a). Glaucoma and antioxidants: Review and update. Antioxidants, 9(11), 1031. https://doi.org/10.3390/antiox9111031
Garcia-Medina, J.J., Rubio-Velazquez, E., Foulquie-Moreno, E., Casaroli-Marano, R.P., Pinazo-Duran, M.D., Zanon-Moreno, V., & del-Rio-Vellosillo, M. (2020b). Update on the effects of antioxidants on diabetic retinopathy: In vitro experiments, animal studies and clinical trials. Antioxidants, 9(6), 561. https://doi.org/10.3390/antiox9060561
Franco, R., Navarro, G., & Martínez-Pinilla, E. (2019). Hormetic and mitochondria-related mechanisms of antioxidant action of phytochemicals. Antioxidants, 8(9), 373. https://doi.org/10.3390/antiox8090373
Hrelia, P., Sita, G., Ziche, M., Ristori, E., Marino, A., Cordaro, M., Molteni, R., Spero, V., Malaguti, M., Morroni, F., & Hrelia, S. (2020). Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system. Oxidative Medicine and Cellular Longevity, 2020, Article ID 8363245. https://doi.org/10.1155/2020/8363245
Sguizzato, M., Mariani, P., Spinozzi, F., Benedusi, M., Cervellati, F., Cortesi, R., Drechsler, M., Prieux, R., Valacchi, G., & Esposito, E. (2020). Ethosomes for coenzyme Q10 cutaneous administration: From design to 3D skin tissue evaluation. Antioxidants, 9(6), p.485. https://doi.org/10.3390/antiox9060485
Budani, M.C., & Tiboni, G.M. (2020). Effects of supplementation with natural antioxidants on oocytes and preimplantation embryos. Antioxidants, 9(7), 612. https://doi.org/10.3390/antiox9070612
Bhattacharjee, S., & Sengupta, A. (2009). Spices in cancer prevention: an overview. Internet. J. Nutr. Wellness, 7(1), 13. https://doi.org/10.5580/b0c
Kaefer, C.M., & Milner, J.A. (2008). The role of herbs and spices in cancer prevention. The Journal of Nutritional Biochemistry, 19(6), 347-361. https://doi.org/10.1016/j.jnutbio.2007.11.003
AllwynSundarRaj, A., Aaron, S., Seihenbalg, S.S., Tiroutchelvamae, D., & Ranganathan, T.V. (2014). Review on - Recent trends in isolation of antioxidants from spices and its biological effects of essential oils. J. Eng. Res. Appl., 4, 75-84.
Yashin, A., Yashin, Y., Xia, X., & Nemzer, B. (2017). Antioxidant activity of spices and their impact on human health: A review. Antioxidants, 6(3), 70. https://doi.org/10.3390/antiox6030070
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